Immune response in T1D

Recruiting to: ongoing

Summary

We are inviting people with and without T1D to identify the immune mechanisms that are driven by genome variations that are associated with protection from T1D development in people with and without other diabetes genetic risk factors. We will explore people’s immune cells to see how functional those cells are, and whether there are differences in their phenotype in individuals that have protective genes compared to those that have gene variations that suggest increased risk to T1D development.

Contact us
Call: 020 7594 3735

Email: m.dominguez-villar@imperial.ac.uk

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ELSA – EARLY SURVEILLANCE FOR AUTOIMMUNE DIABETES

Recruiting to: ongoing

‘Sooner we screen, sooner we can intervene’

Aim

The ELSA Study is screening children aged from 3-13 years to determine their risk of developing type 1 diabetes.

Who can take part?

ANY child aged 3-13 years who does not currently have type 1 diabetes. There is no need for the child to be from a family where someone has type 1 diabetes – children from any family can be tested.

What does the ELSA study involve?
Parents/guardians willing for their child/ren to take part in the ELSA Study can complete the consent form online or by post. The screening test is a simple finger-stick blood test. The home testing kit is available to families across the United Kingdom and this will be sent by post with instructions and a video of how to perform the test.

For any child found to be at risk of type 1 diabetes in the future, we will invite the family to attend a one-to-one education session to explain what the results mean. We will also refer the family to further research studies their child may be eligible for, including monitoring follow-up and prevention trials.

For more information, please visit our online information tool for parents: https://elsa-info.digitrial.com/get-started

For any queries, please contact the ELSA Study Team:

Online contact form: https://elsadiabetes.nhs.uk/contact-us/

Call: 0121 414 7814 (Monday – Friday, 9-5pm)

Email: elsa@contacts.bham.ac.uk

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Who is running this study?
The ELSA study is being run by the University of Birmingham and led by Professor Parth Narendran. The ELSA study is co-funded by Diabetes UK and JDRF.

Recruiting sites

Recruiting nationally via online and postal systems to all eligible families in the UK.
Open to recruitment:

Birmingham Children’s Hospital
Birmingham Community Healthcare Trust
University Hospitals Sussex NHS
Cambridge Addenbrooks Hospital
Royal Devon and Exeter Hospital, Exeter
East Lancashire Royal Blackburn Hospital
Leeds Children’s Hospital
Alder Hey Children’s Hospital
Barts Health NHS Trust
Royal Free Hospital, London
Newcastle Royal Victoria Infirmary
Nottingham Queen’s Medical Centre
Oxford University Hospital
University Hospital Southampton
Surrey and Sussex Healthcare NHS Trust
Royal Aberdeen Children’s Hospital
NHS Tayside
West Glasgow Ambulatory Care Hospital
Southern Health and Social Care Trust

Opening soon

Royal Infirmary of Edinburgh

What will I be asked to do?

In the ELSA Study, we are screening children for type 1 diabetes. The study has 5 steps:

Step 1 – Finger prick blood test to screen for antibodies (20,000 children)
Step 2 – Venous blood test to test for antibodies (for children who screened positive at stage 1)
Step 3 – Venous blood tests for staging of type 1 diabetes (for children who tested positive at stage 2)
Step 4 – Education session (for parents of children at-risk)
Step 5 – Interviews with parents/guardians to provide feedback on the screening programme

What are we testing for?
In the ELSA study, we are testing for antibodies (protein markers in the blood) because antibodies are markers of risk of type 1 diabetes. There are 4 antibodies we are testing for in the ELSA Study.

As the number of antibodies a child has rises, this increases their risk of developing type 1 diabetes in the future. For example, for children who have 2 of these antibodies, within the next 10 years, 3 in 4 of these children will develop symptoms of type 1 diabetes.

For children who have 1 of these antibodies present, their risk is not as high, but they could develop more antibodies over time.
For children who do not have any of these antibodies, this means they are currently at low risk of developing type 1 diabetes. But, they could still develop antibodies in the future

3 in 1000 children are at high risk of getting type 1 diabetes and we can only find these children by screening.